A-a gradient = PAO2 - PaO2 PaO2 (partial pressure of O2 in the - TopicsExpress

A-a gradient = PAO2 - PaO2 PaO2 (partial pressure of O2 in the artery) --obtained from the arterial blood gases. PAO2 (partial pressure of O2 in the alveoli)-- obtained from the Alveolar Gas equation. Alveolar gas equation: PAO2 = PiO2 - (PaCO2 / R) PiO2 = FiO2 (PB - PH2O) or using common values: PA02 = ( FiO2 * (760 - 47)) - (PaCO2 / 0.8) *PiO2 = partial pressure of O2 in the central airways *FiO2 (fraction of inspired oxygen) FiO2 on room air = 0.21 *PaCO2 (value from your ABG). *PB = barometric pressure (760 mmHg at sea level) PB = PN2 + PO2 + PCO2 +PH2O *PH2O = Water vapor pressure (47 mm Hg at 37 degrees celcius) *R = Respiratory quotient = VCO2 / VO2 = 0.8 (usual) (ratio of carbon dioxide production to oxygen consumption.) Estimating A-a gradient: Normal A-a gradient = (Age+10) / 4 A-a increases 5 to 7 mmHg for every 10% increase in FiO2

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