A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in celiac disease Abstract Title: Markers of Celiac Disease and Gluten Sensitivity in Children with Autism. Abstract Source: PLoS One. 2013 ;8(6):e66155. Epub 2013 Jun 18. PMID: 23823064 Abstract Author(s): Nga M Lau, Peter H R Green, Annette K Taylor, Dan Hellberg, Mary Ajamian, Caroline Z Tan, Barry E Kosofsky, Joseph J Higgins, Anjali M Rajadhyaksha, Armin Alaedini Article Affiliation: Department of Medicine, Columbia University, New York, New York, United States of America ; Celiac Disease Center, Columbia University, New York, New York, United States of America. Abstract: OBJECTIVE: Gastrointestinal symptoms are a common feature in children with autism, drawing attention to a potential association with celiac disease or gluten sensitivity. However, studies to date regarding the immune response to gluten in autism and its association with celiac disease have been inconsistent. The aim of this study was to assess immune reactivity to gluten in pediatric patients diagnosed with autism according to strict criteria and to evaluate the potential link between autism and celiac disease. METHODS: Study participants included children (with or without gastrointestinal symptoms) diagnosed with autism according to both the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview, Revised (ADI-R) (n=37), their unaffected siblings (n=27), and age-matched healthy controls (n=76). Serum specimens were tested for antibodies to native gliadin, deamidated gliadin, and transglutaminase 2 (TG2). Affected children were genotyped for celiac disease associated HLA-DQ2 and -DQ8 alleles. RESULTS: Children with autism had significantly higher levels of IgG antibody to gliadin compared with unrelated healthy controls (p
Posted on: Thu, 18 Jul 2013 04:01:46 +0000
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