B-CELLS AND LUPUS B-cells play a prominent role in lupus...see more at: medpagetoday/Rheumatology/Lupus/46493 B cells are types of lymphocytes (white blood cells) manufactured in the bone marrow that make antibodies. An antibody is used by the immune system to identify and neutralize foreign objects such as bacteria, viruses, and protein fragments. So, if lupus originates with missing enzymes that digest dietary proteins and DNA - protease and DNase 1 - (please see previous post) then how would a lack of these enzymes lead to the involvement of B-cells? Protease and DNase 1 digest dietary proteins and release essential amino acids. Research confirms that patients with lupus are deficient in all of the essential amino acids, including the essential amino acid phenylalanine. Phenylalanine is needed to produce the neurotransmitter dopamine (phenylalanine>tyrosine>dopamine). Dopamine regulates the hormone prolactin. Dopamine restrains prolactin. The B-cells in lupus are being activated by elevated levels of prolactin. As the following study confirms, prolactin interferes with B cell tolerance and promotes autoreactivity. Prolactin alters the mechanisms of B cell tolerance induction. Saha, S., et. al. 2009. Arthritis Rheum. 60(6):1743-52. “…Persistently elevated serum prolactin levels interfere with B cell tolerance induction…thereby promoting autoreactivity.” As the following study confirms, lupus patients have elevated levels of prolactin. Prolactin in human systemic lupus erythematosus. Jara, L.J., O. Vera-Lastra, J.M. Miranda, M. Alcala, J. Alvarez-Nemegy- ci. 2001. Lupus. vol. 10 no. 10748-756 “In the last decade, evidence has accumulated to support the hypothesis that both mild and moderate elevations of serum prolactin (PRL) participate in the clinical expression and pathogenesis of systemic lupus erythematosus (SLE)… Medications, such as Atacicept, would only be targeting one aspect of the lupus disease process (B-cell autoreactivity) that results from an inability to digest dietary proteins and DNA. The restoration of protease and DNase 1 would address the entire lupus disease process. I completely recovered from lupus after suffering for more than 20 years by restoring these missing enzymes through diet and lifestyle changes and healing my GI tract.
Posted on: Fri, 27 Jun 2014 01:09:19 +0000
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