Cell Biology and Toxicology April 2013, Volume 29, Issue 2, pp - TopicsExpress

Cell Biology and Toxicology April 2013, Volume 29, Issue 2, pp 75-84 How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale Sungwon Han, Joseph Lemire, Varun P. Appanna, Christopher Auger, Zachary Castonguay, Vasu D. Appanna Abstract Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes. This Al-evoked phenomenon is coupled to diminished mitochondrial activity, anerobiosis, and the channeling of α-ketoacids towards anti-oxidant defense. The resulting metabolic reconfiguration leads to fat accumulation and a reduction in ATP synthesis, characteristics that are common to numerous medical disorders. Hence, the ability of Al toxicity to create an oxidative environment promotes dysfunctional metabolic processes in astrocytes and hepatocytes. These molecular events triggered by Al-induced ROS production are the potential mediators of brain and liver disorders. link.springer/article/10.1007%2Fs10565-013-9239-0

Weve been working to pass the Keystone XL pipeline for four years

hola gente, hoy les traigo un dato muy curioso... todos conocemos

See I never thought that I could walk through fire. I never

Telangana state before new year: Jaipal reddy Nov 10, 2013,

I was angry with my friend: I told my wrath, my wrath did end. I

Daily Trust shared the following link and had this to say about

I know that not all of my friends are baseball fans, but for those

HARUSKAH KUBERTAHAN JIKA RASA PERCAYA ITU TAK ADA

St. John Paul II Pilgrims and happy Roman Catholics were

Mourinho proposes a toast! Chelsea boss hopes club have reason to

Indien fällt einzigartiges Urteil für Delfine Indien Indien hat

:-P Kapil was lying on beach, . American : R u Relaxing ?

The Lakers have waived forward Metta World Peace and have

FOR PREGNANT USE OMEGA SUPREME CHOLEDUZ! Heath benefits of

At least eighteen people have been killed and several others

Decade/Dolav Bulk Containers - 48Wx40Lx31H Bulk Container - Blue

The Birthday of Man – Let us celebrate! Let us say “Happy

We never know how strong we truly are until we or our loved ones

Explore uk ltd ( exploreyorkshiredistrict.co.uk ) presents a

Touching Story of the Night Once upon a time, there lived a big

CHỨNG NHẬN : HẾT ỐM Ad gữi quà bên bưu điện

O Espírito Santo Incendiará Sua Vida admin 1 comentário O

Osho on Suicide Osho on Suicide – Ordinary suicide will-not

he Bullet Riddled Dead Bodies Found in Bolan

HENRY PURCELL (1659 – 1695) So When The Glittring Queen of

KIZOMBA DATING HORS SERIE !! OPERATION 007 !!! 0 COURS 0 SHOW 7H

ALGO SOBRE SAN GABRIEL La palabra Arcángel proviene de dos

Hes a man of incomparable personality , immensely rich in

So today we made it back to Gambia safe and sound to see our host

Meet Elmer {everyones favorite cashier} with Mrs. Elmer another