How do cells talk to each other? How does this help tissue engineers? - by Yanny Marliana Baba Ismail Do you know that cells communicate with each other? People usually communicate using speech, sign language, short notes, email or social media, to name but a few. Believe it or not, cells have their very own communication system. There have been extensive research efforts to develop new strategies for bone tissue engineering. One popular approach is pre-seeding the scaffold with endothelial cells and bone forming cells which are assumed to improve angiogenesis (forming new blood vessels from pre-existing vessels) and bone regeneration simultaneously through a complex dialogue between the two cell types. The crosstalk between endothelial cells and bone forming cells produces growth factors affecting the growth and differentiation of both cell types. Growth factors are naturally occurring substances (usually protein-based) that are important in regulating cellular responses. As the scaffold is in contact with both endothelial cells and bone forming cells, the growth factors produced by endothelial cells can then affect the migration and proliferation of bone forming cells and thus leads towards osteogenic differentiation. On the other hand, bone forming cells produce growth factors which increase the survival time and proliferation of endothelial cells and stimulate differentiation and angiogenesis through activation of specific receptors. Interactive communication between endothelial cells and bone forming cells is vital to creating a live scaffold, that can be used in bone tissue engineering! youtu.be/xnGXItWrJ3k
Posted on: Thu, 18 Dec 2014 12:02:42 +0000
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