I just had this flash of insight that many people may not tolerate a low carbohydrate diet specifically because it increases fat oxidation and metabolism. Rather like exercise intolerance, low carbohydrate diet intolerance likely reflects an inability to cope with any diet that would disinhibit fat oxidation and the sympathetic nervous system. These would include people with primary hypothyroidism who need medication, people with CFS and mitochondrial insufficiencies. Speaking of myself it took me a year to feel normal on VLC, and i strongly feel this represented a timeframe of mitochondrial biogenesis. The reason I can tolerate very LC diets now is because I have many dense mitochondria that are healthy, which is well known to occur during calorie restriction, low cal diets, and is inverse what happens in chronic overnutrition as in diabetes. Those who constantly feel fatigued, beat down, never able to adapt to low carb, likely have a primary or secondary mitochondrial pathology which makes them intolerant of interventions that increase the SNS, or increase fat oxidation. We would also hypothesize they would experience similar intolerance of exercise/activity for same reason; activity and exercise, also increase SNS and fat oxidation via glucose depletion. Many mitochondrial problems improve on keto, but these are more the mitochondrial disorders affecting glucose oxidation specifically. I would expect low carb diet intolerance to be more a generalized mitochondrial deficiency, or perhaps a disease of the SNS and thyroid hormone function (which is a slave of the SNS, by the way). As stated, we can also expect it to cluster with inability to exercise or elicit energy *at all*.
Posted on: Thu, 08 May 2014 02:24:21 +0000
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