[LT] Desafiando a Nomenklatura Científica Desafiando a Nomenklatura Cientfica /////////////////////////////////////////// Perfis quantitativos dos peptdeos de RNA classificados como no-codificante: no LIXO! Tem FUNO!!! Posted: 19 Nov 2014 06:17 AM PST feedproxy.google/~r/blogspot/dDNr/~3/fvAyQi18rdM/perfis-quantitativos-dos-peptideos-de.html?utm_source=feedburner&utm_medium=email Quantitative profiling of peptides from RNAs classified as noncoding Sudhakaran Prabakaran, Martin Hemberg, Ruchi Chauhan, Dominic Winter, Ry Y. Tweedie-Cullen, Christian Dittrich, Elizabeth Hong, Jeremy Gunawardena, Hanno Steen, Gabriel Kreiman & Judith A. Steen Nature Communications 5, Article number: 5429 doi:10.1038/ncomms6429 Received 28 May 2014 Accepted 30 September 2014 Published 18 November 2014 Source/Fonte Abstract Only a small fraction of the mammalian genome codes for messenger RNAs destined to be translated into proteins, and it is generally assumed that a large portion of transcribed sequences—including introns and several classes of noncoding RNAs (ncRNAs)—do not give rise to peptide products. A systematic examination of translation and physiological regulation of ncRNAs has not been conducted. Here we use computational methods to identify the products of non-canonical translation in mouse neurons by analysing unannotated transcripts in combination with proteomic data. This study supports the existence of non-canonical translation products from both intragenic and extragenic genomic regions, including peptides derived from antisense transcripts and introns. Moreover, the studied novel translation products exhibit temporal regulation similar to that of proteins known to be involved in neuronal activity processes. These observations highlight a potentially large and complex set of biologically regulated translational events from transcripts formerly thought to lack coding potential. Subject terms: Biological sciences Molecular biology Bioinformatics Source/Fonte: Nature Communications +++++ Professores, pesquisadores e alunos de universidades públicas e privadas com acesso ao site CAPES/PERIÓDICOS podem ler gratuitamente este artigo da Nature Communications e de mais 37.000 publicações científicas. +++++ NOTA DESTE BLOGGER: E o lixo biológico cada vez mais se mostrando um tesouro. Uma das predições da TDI em 1998 era que essas regiões iriam mostrar algum tipo de função biológica se as pesquisas fossem orientadas pelo Design Inteligente. William Dembski, a cada dia sua predição é confirmada. E pelos evolucionistas honestos -- You are subscribed to email updates from Desafiando a Nomenklatura Cientfica. To stop receiving these emails, you may unsubscribe now: https://feedburner.google/fb/a/mailunsubscribe?k=TwN2DaWnBhfhsAln1l2BmLcmKk4 Email delivery powered by Google. Google Inc., 1600 Amphitheatre Parkway, Mountain View, CA 94043, United States -- -- -- Você recebeu esta mensagem porque está inscrito no grupo de notícias católicas Emitte lucem tuam. Para cancelar a sua inscrição neste grupo, envie um e-mail para lucemtuam+unsubscribe@googlegroups Para ver mais opções, visite este grupo em groups.google/group/lucemtuam
Posted on: Wed, 19 Nov 2014 19:40:11 +0000
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