Perhaps the largest blow to the mutation theory is a review of 250 - TopicsExpress

Perhaps the largest blow to the mutation theory is a review of 250 published cancer studies and scientific papers recently published in Cancer Metastasis Rev. (June 2012). Based on statistical evidence and mathematical calculations if just one single mutation were responsible for causing cancer, then everyone the world would have multiple cancers the body, and if multiple specific mutations were involved in causing cancer (as is suggested by mutation theorists), then “it is equivalent to the chance of one cancer case in 1.42× 1023 people, meaning no one would get cancer in the world,” according to this scientific review.

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