Review: Body Fat Distribution and Insulin Resistance Subcutaneous - TopicsExpress

Review: Body Fat Distribution and Insulin Resistance Subcutaneous visceral adipose tissue appears to have a major function as a metabolic buffer against insulin resistance. In the presence of positive caloric balance, subcutaneous adipose tissue eventually becomes dysfunctional due to adipocyte hypertrophy, decreased adipogenesis and angiogenesis. At this point, buffering function is lost and excess free fatty acids spill over into ectopic tissues, resulting in tissue specific consequences. Therapeutic lifestyle change continues to be the most important intervention in clinical practice to improve adipose tissue function and avoid development of insulin resistance and related cardio-metabolic complications. Full-text: mdpi/2072-6643/5/6/2019

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