Suzanne Humphries shared: All the campers who got whooping cough were vaccinated against it...whoops!! How can we blame the patient then?? Because it cant be a useless, toxic vaccine that has created a new mutant strain without pertactin that is MORE virulent than the good old strains, right?? washingtonpost/local/education/whooping-cough-outbreak-in-montgomery-includes-students-at-seven-public-schools/2014/09/07/adb5c87c-34fb-11e4-9e92-0899b306bbea_story.html And if you want to read what I mean about pertactin, here is just one of many articles on the pertactin-absent strain that has more invasive and longer lasting quality when infected. ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+22348138 Quote: Prn is an important antigenic component of most current aP vaccines, and it plays a role in eliciting protective immunity, leading to the suggestion that Prn negative strains have escaped the immune response to Prn.Prn2 isolates have a higher growth potential than the Prn+ back-mutants from which they were derived. and FHA [4,5]. In vaccine efficacy trials, the anti-Prn antibody level correlates with clinical protection, suggesting an important role for Prn in immunity [6]. In vitro studies also show that anti-Prn antibody is crucial for opsonophagocytosis. The most likely explanation for prevalence of Prn2 strains is vaccine-driven selection. Prn is an important antigenic component of most current aP vaccines, and it plays a role in eliciting protective immunity [4,6,7,34,35], leading to the suggestion that Prn2 strains have escaped the immune response to Prn. The herd immunity by aP vaccines could exert selective pressure for pathogen evolution, like the emergence of the PT promoter (ptxP3) lineage that produces higher levels of PT. And Stefanelli says ncbi.nlm.nih.gov/pubmed/?term=19579693 Overall, these results show that the enhanced ability of the PRN- strain to invade/infect MDCC suggest that the PRNantigen may play a role in...
Posted on: Tue, 16 Sep 2014 02:15:07 +0000
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