The potent hallucinogenic effects of pure DMT in humans were first - TopicsExpress

The potent hallucinogenic effects of pure DMT in humans were first reported by Szara [7] in 1956. Then, in 1965, DMT, tryptamine and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) were reported as normal constituents of human urine and blood [8] [...] We have reviewed the current research on INMT and AADC activity, illustrating that their participation in DMT biosynthesis is biochemically very reasonable. We have also proposed a major role for DMT in the trace amine system. This proposal offers a neurochemical explanation for heretofore ill-understood aspects of DMT pharmacology, especially at low doses. Our proposed scenario also includes the hypothesis that increased DMT or tryptamine production could suppress psychotic activity, rather than aggravate it. (Jacob and Presti, 2005)

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