The protective effect of cannabinoids in traumatic brain injury - TopicsExpress

The protective effect of cannabinoids in traumatic brain injury was first indicated in studies with the nonpsychotropic cannabinoid dexanabinol (HU-211) (Fig. 1b). These studies have demonstrated reduced brain damage and improved motor and cognitive function in HU-211-treated animals in a rat model of TBI. The favorable effects of a single injection of HU-211 on learning and neurological deficits lasted up to 30 days and could be achieved within a therapeutic window of 6 h (Shohami et al., 1993, 1995).

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