This could do for HIV prevention in discordant couples, what the - TopicsExpress

This could do for HIV prevention in discordant couples, what the long-acting IM contraceptive DepoProvera, did for contraception... Working with researchers from drugmaker GlaxoSmithKline (GSK) in Research Triangle Park, North Carolina, and the Tulane National Primate Research Center in Covington, Louisiana, Ho and his colleagues tested an experimental drug, dubbed GSK744, that inhibits an enzyme the virus depends on to integrate into human chromosomes and copy itself. The integrase inhibitor is an analog of a GSK pill called dolutegravir, which the FDA approved in August 2013 to treat HIV infections. An offshoot of GSK, ViiV Healthcare, initially began developing GSK744 as an injectable treatment, not a preventative; small human safety and pharmacokinetic studies have been completed. -- Were actually using dolutegravir now in HIV+ patients as part of ART (Antiretroviral Combination Therapy)-- its safe, and very well-tolerated by patients. So promising!

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