WHERE THE CANCER RESEARCHER THAT BELIEVES IN THE GENETIC (THEREFORE EPIGENETIC) ORIGIN OF CANCER HAS GOT IT ALL WRONG. Obviously the growth of cancer cannot be tracked in a human subject from its induction until it become malignant and metastasizes, or even forms multiple metastasis and kills the research subject. Its not considered ethical to do so. So the cancer researcher takes cells from a human tumor, eg a breast ductal cell carcinoma. He then sorts them to separate out the cancer STEM CELLS from the cancer NON STEM CELLS. Then he injects the cancer stem cells into a mammary of a mouse whose immune system has been suppressed, although suppressing immunity is not relevant here. The cancer stem cells injected into the mouse grow into a tumor, by DIFFERENTIATION, (going forward) just as happens in NORMAL TISSUE. So he makes the presumption that this is how a tumor develops normally, the difference being that to BECOME A CANCER STEM CELL, as Ive already stated, a normal tissue stem cell is presumed to suffer several spontaneous hits or mutations to TRANSFORM it. It then differentiates in the mouse to form a colony comprised of predominantly NON STEM CANCER CELLS and some CLONES OF THE CANCER STEM CELLS INJECTED. However he is injecting the cancer stem cells into WELL OXYGENATED tissue in the mouse. So given this HIGH OXYGEN TENSION the cancer stem cells GO FORWARD by DIFFERENTIATION. He is NOT linking oxygen tension with GOING FORWARD or GOING BACKWARD at all. This is in part because the word DEDIFFERENTIATION (going backward) almost disappeared from the lexicon. Thus the mistake is a laboratory artifact. However the word DEDIFFERENTIATION is bouncing back. Now research is showing what I have been saying for around 20 years that it is HYPOXIA that transforms DIFFERENTIATED cells committed to apoptosis (cell suicide) into NON STEM cancer cells that DEdifferentiate to eventually give rise to CANCER STEM CELLS as the OXYGEN TENSION progressively goes down in the CENTER of the tumor, (as it expands), where its MOST HYPOXIC. In other words oxygen tension is the PRIMARY DIFFERENTIATION FACTOR. (My hypothesis which pans out perfectly.) Going on line I cannot find any thing that says that oxygen tension IS the primary differentiating factor yet it seems so obvious.. So they are close but not close enough, now pipped at the post by yours truly. In other words in normal tumors CANCER STEM CELLS come from NON STEM CANCER cells and not the other way down. TOP DOWN not BOTTOM UP. ncbi.nlm.nih.gov/pubmed/16144692 ncbi.nlm.nih.gov/pubmed/12880974 ncbi.nlm.nih.gov/pubmed/12670886 cancerres.aacrjournals.org/content/63/7/1441.fullblogs.scientificamerican/guest-blog/2013/01/11/dedifferentiation-turning-back-the-cellular-clock/ From your lab Bob Weinberg.. pnas.org/content/early/2011/04/14/1102454108.full.pdf Is ANYTHING spontaneous in Nature, or does this mean cause unknown, or got it the wrong way round Bob, you and just about everyone else? TREATMENT. If we take the conventional view that cancer derives from a series of spontaneous mutations, or even if we accept that hypoxia makes tumors more aggressive and resistant to therapy, but that this hypoxia is simply a stuff up due to ANGIOGENESIS BEING UNABLE TO KEEP UP WITH PROLIFERATION, or mitachondrial damage inhibiting oxidative phosphorylation (aerobic metabolism) then there is justification for cut, poison and burn as the tumor is simply something alien that is a product of chance. However what if the tumor is induced by hypoxia, especially if it is PROGRAMMED to do so. ncbi.nlm.nih.gov/pubmed/17656037 news-medical.net/news/20120504/Hypoxia-may-be-a-primary-cause-of-uncontrollable-tumor-growth-in-cancers.aspx cambridgemedscience.org/articles/medhyp-08.pdf complementaryoncology/reports/others/cell-hypoxia-the-prime-cause-of-cancer-on-cell-level/ chronicles.franklin.uga.edu/posts/new-study-links-hypoxia-cancer-growth 800 genes turned on or off by hypoxia This means that cancer should be completely curable by REVERSING the oxygen tension by eliminating the stress that is constricting the normal blood vessels supplying the tumor AND getting rid of the gunk in blood vessels with a KETONE diet. As the ketone diet almost eliminates glucose from the bloodstream then the MALIGNANT STEM CELLS given to METASTASISE will be wiped out, killed, garrotted, euthenased, murdered, assassinated etc. because THEY MUST HAVE GLUCOSE, operating ANAEROBICALLY as they do. Liver health will have to be restored as well but I dont want to get into that subject here. .
Posted on: Tue, 28 Oct 2014 22:44:24 +0000
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