good changes in medications that have Tylenol/acetaminophen due to so much liver damage and deaths- from Medscape! Between 1998 and 2003, acetaminophen was the leading cause of acute liver failure in the United States, with 48% of these acetaminophen-related cases of liver failure being associated with accidental overdoses. Summarizing data from 3 different surveillance systems, there were an estimated 56,000 emergency department visits, 26,000 hospitalizations, and 458 deaths related to acetaminophen-associated overdoses per year from 1990 through 1998. A study from 22 medical centers in the United States that was completed in 2003 and was confirmed in a separate study in 2007, demonstrated that a high percentage of instances of liver injury due to acetaminophen were related to unintentional overdoses. In other words, the patient took too much by mistake. As part of the US Food and Drug Administrations (FDA) Safe Use Initiative in 2011, the Acetaminophen Best Practices Task Force was created. The Task Force produced a white paper recommending complete disclosure of acetaminophen in all acetaminophen-containing products, a standard pharmacy warning label about liver damage for these medications, and specific wording on pharmacy container labels that is consistent with appropriate health literacy principles-- ie, these had to be specially designed so that people could [understand] them. On January 14, 2014, the FDA recommended[1] that healthcare professionals discontinue prescribing and dispensing prescription combination drug products that contain more than 325 mg of acetaminophen per tablet, capsule, or other dosing form. Even before that, in 2011 the FDA had asked manufacturers of prescription combination drug products containing acetaminophen to limit the amount of acetaminophen to no more than 325 mg in each tablet, capsule, or other dosing method by January 14, 2014.
Posted on: Mon, 28 Apr 2014 17:32:16 +0000
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