#md_start A70-year-old man with a 60 pack-year smoking history - TopicsExpress

#md_start A70-year-old man with a 60 pack-year smoking history presents with cough and weight loss. He describes recent diffuse darkening of his skin and his CXR shows a mass suspicious for lung cancer in the left hilum. His laboratory tests reveal hypokalemia. Which of the following is the most likely histology of his lung cancer? (A) adenocarcinoma (B) small cell (C) squamous cell (D) mesothelioma (E) glioblastoma .. .. .. .. Answer: (B) Endocrine syndromes are seen in 12% of patients with lung cancer. Squamous cell carcinoma is associated with PTH-related peptide. Adrenocorticotrophic hormone (ACTH) and ADH secretion can be associated with small cell lung carcinoma. ACTH-secreting tumors are associated with darkening of the skin and hypokalemia

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