2007 encodeproject.org/ENCODE/ DNA from a long-ago invader gives human embryonic stem cells the power of transformation. Molecule that encodes the genetic instructions used in the development and functioning of all known living organisms The protein encoded by this gene is an ATP-dependent DNA ligase that joins double-strand breaks during the non-homologous end joining pathway of double-strand break repair. It is also essential for V(D)J recombination. Lig4 forms a complex with XRCC4, and further interacts with the DNA-dependent protein kinase (DNA-PK) and XLF/Cernunnos, which are also required for NHEJ. The crystal structure of the Lig4/XRCC4 complex has been resolved. https://genome.ucsc.edu/ genome.gov/10005107 Timez ftp.ebi.ac.uk/pub/databases/ensembl/encode
Posted on: Thu, 21 Aug 2014 01:03:52 +0000
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