Anandamide has important anti-inflammatory and anti-cancer - TopicsExpress

Anandamide has important anti-inflammatory and anti-cancer properties both in vivo and in vitro in animal models. It affects the cardiovascular system by inducing profound decreases in blood pressure and heart rate. In addition, it is an anabolic regulator of metabolism in that it increases the intake of food, promotes the storage of lipid, and decreases the expenditure of energy. It is also involved in the regulation of body temperature, locomotion, feeding and anxiety. Some of these effects appear to be independent of the two main receptors, and anandamide is known to bind to a number of other proteins including the peroxisome proliferator-activated receptors (PPARα and PPARγ). There are suggestions that modulation of anandamide levels in the gut has potential for treatment of inflammatory bowel disease and colon cancer. Anandamide is present in the reproductive fluids of both males and females and is believed to be important in reproduction.

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