Are our researchers wrong or is ASEA safer by balancing the redox signaling pathways. If we read this article it seems that science wants to disbalance the ROS and their opposite molecules. It seems to me that we are on the safer side by providing a perfect balanced supplement to our body. Abstract of the article: Preclinical Research Cancer metastasis is the major cause of cancer-related mortality. Accumulated evidence has shown that high-metastasis potential cancer cells have more reactive oxygen species (ROS) accumulation compared with low-metastasis potential cancer cells. ROS can function as second messengers to regulate multiple cancer metastasis-related signaling pathways via reversible oxidative posttranslational modifications of cysteine in key redox-sensitive proteins, which leads to the structural and functional change of these proteins. Because ROS can promote cancer metastasis, therapeutic strategies aiming at inducing/reducing cellular ROS level or targeting redox sensors involved in metastasis hold great potential in developing new efficient approaches for anticancer therapy. In this review, we summarize recent findings on regulation of tumor metastasis by key redox sensors and describe the potential of targeting redox signaling pathways for cancer therapy.
Posted on: Thu, 11 Sep 2014 07:58:38 +0000
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