Cell Biology Weekend Question: Protein folding has a Gibbs Free - TopicsExpress



          

Cell Biology Weekend Question: Protein folding has a Gibbs Free Energy of -10kcal/mole. Proteins have on average about 100 (my number) noncovalent bonds and interactions. If we estimate that noncovalent interactions have an average standard free energy of -1kcal/mole the protein should have a calculated free energy of -100kcal/mole -- this is the sum of free energy from 100 noncovalent interactions. We calculate -100 but measure only -10? How do you explain this difference?
Posted on: Sat, 12 Oct 2013 15:39:38 +0000

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