ESTRADIOL via INTRA-NASAL SPRAY?: A Puzzlement.... It seems that there has been a method of administering Estradiol with a nasal spray for years...mostly arising and used in France, apparently. Quite surprisingly we have never heard of it before. Certainly food for thought and not clear why this is so unknown and unpublicized. So, anyone out there in TG Land who has ever encountered this novel form of HRT, please let us know? Apparently, the efficacy of Estradiol-Intranasal 300 microg/day was similar to that of oral estradiol 2 mg/day It seems from the several studies we have listed below, Intranasal and Transdermal estrogen delivery systems had equivalent efficacy and similar safety profiles. Intranasal therapy was the patients choice for long-term treatment by those who had tried both. Down below, pending further investigation of this interesting way of administering estradiol, we are listing the full abstracts so we all can take a look at what they say. Perhaps some of you out there will have encountered some further information about this mode of administration? Here then is a series of studies, we have found: Randomized Comparison of Intranasal and Transdermal Estradiol. Women and Childrens Hospital, Nantes, France. [email protected] OBJECTIVE: To compare the efficacy and patient acceptability of intranasal versus transdermal 17 beta-estradiol (E2) delivery systems for postmenopausal symptoms. METHODS: Postmenopausal women were randomly assigned to intranasal 17 beta-E2, 300 microg daily (n = 176) or transdermal 17 beta-E2 (delivering 50 microg/day), two patches per week (n = 185) for 12 weeks, followed by a 4-week period with the alternate treatment. Efficacy was compared between groups using the Kupperman Index and vasomotor symptoms at week 12. Patient acceptability was compared by patient choice of administration route and by questionnaire at week 16. RESULTS: Intranasal and transdermal therapy produced significant reductions in the Kupperman Index and in the occurrence of hot flushes and night sweats at week 12. Alleviation of climacteric symptoms was statistically equivalent in the two treatment groups (P
Posted on: Sun, 16 Feb 2014 23:13:47 +0000