Enzyme Inhibitors Suppress Herpes Simplex Virus Replication, study finds #NTS enzyme inhibitors are promising candidates for new #herpes virus Rx. The findings could lead to new treatment options for herpes that patients can use in conjunction with or instead of currently approved anti-viral medications like #Acyclovir. Researchers likened a combination of treatments for herpes to a cocktail of medications HIV patients take. Americans are impacted by cold sores (#HSV-1) and 20% suffer from genital herpes (#HSV2). Herpes can be passed from mother to child during childbirth posing serious health risks to both the baby and the new mother. HSV2 also increases the risk of #HIV acquisition + HSV #encephalitis >>Saint Louis U researchers investigated whether inhibitors of NTS enzymes would suppress replication of HSV-1 and HSV-2 #MOA: they suppressed accumulation of #viral #genomes and infectious particles and blocked events in the viral replication cycle before and during viral DNA replication. 5 of 6 NTS inhibitors of the HSVs also blocked replication of another herpes virus pathogen, #human #cytomegalovirus. They are now focused on expanding their original small scale study to identify the exact mechanisms by which each inhibitor suppresses virus replication. 1 compound has already proven effective in #animals and another is found in a topical #antifungal already FDA approved for use. slu.edu/x99601.xml
Posted on: Sun, 21 Dec 2014 17:47:38 +0000
Trending Topics
Recently Viewed Topics
© 2015