FRUCTOSE IMPROVES GLYCEMIC CONTROL IN DIABETES In conclusion, aggregate analyses of short-term controlled feeding trials showed that isocaloric fructose replacement of other carbohydrates resulted in clinically significant improvements in glycemic control, equivalent to a ∼0.53% reduction in HbA1c, without significantly affecting insulin in diabetic individuals. This benefit was seen across a full dose range (20–160 g/day), including at doses below the CDA threshold of 60 g/day, a level of exposure that is unlikely to have an adverse effect on other aspects of metabolic control. The harm-reduction approach to fructose taken by diabetes associations (2,7,8), which is based on possible adverse serum lipid effects, may need to be reconciled with a possible glycemic benefit. These conclusions, however, are limited by the short follow-up, small sample size, and poor quality of most trials included in our meta-analysis, as well as the large degree of unexplained significant heterogeneity. Larger, longer, and higher-quality trials of controlled fructose feeding that also weigh any possible glycemic benefit against adverse metabolic effects are required for definitive confirmation of these findings.
Posted on: Fri, 16 Aug 2013 05:33:43 +0000
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