HIGHER CONCENTRATIONS OF TESTOSTERONE AND REDUCTION OF ITS CONVERSION TO DIHYDROTESTOSTERONE MAY REDUCE THE RISK OF SYMPTOMATIC BPH In summary, we found no evidence that higher levels of testosterone or estradiol increase the risk of symptomatic BPH. To the contrary, we found that higher concentrations of testosterone relative to 17β-diol-glucuronide (measuring indirectly the conversion of testosterone to dihydrotestosterone in the prostate), as well as testosterone and estradiol, were associated with reduced risk. The consistency of findings on both 17β-diol-glucuronide controlled for testosterone and testosterone:17β-diol-glucuronide ratio with the published literature and the known effects of 5-α-reductase inhibitors suggests that either genetic or environmental factors that reduce the conversion of testosterone to dihydrotestosterone may reduce the risk of symptomatic BPH.
Posted on: Thu, 11 Jul 2013 09:52:47 +0000
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