Maximum likelihood based phylogenetic analysis of the HSV-1 strains produced a six clade tree topology that correlated with the geographic origin of the isolate with one exception, HSV-1 KOS. Earlier phylogenetic work with single genes from the Unique Short region of the genome (US1, US4, US7 and US8) consistently produced a three clade pattern. [20], [21], [22] Recently, analysis with modest numbers of genomes from Europe and North Americans of European ancestry also yielded a three clade tree topology. [23] These results provide support for three sub-clades originating in Europe. Here, for the first time, a global sampling was used for a phylogenetic analysis. The topologic placement of the isolates in this study broke down along strict geographic lines (Figures 1 and 2); Europe/North America, East Asia, and Africa. This finding supports the hypothesis that Alphaherpesviruses co-evolved with their hosts [1] and the “out of Africa” theory of human evolution [39], [40]. plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0076267
Posted on: Wed, 06 Nov 2013 17:09:26 +0000
Trending Topics
Recently Viewed Topics
© 2015