More evidence on the hygiene hypothesis and autoimmune disease, for those of you interested in the human microbiome research: Tracing Arthritis to Bugs in the Gut? Published: Nov 8, 2013 | Updated: Nov 8, 2013 By Nancy Walsh, Staff Writer, MedPage Today Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania and Dorothy Caputo, MA, BSN, RN, Nurse Planner Action Points The study found that the presence of Prevotella copri in stool samples strongly correlated with disease in new-onset untreated rheumatoid arthritis patients. The increases in Prevotella abundance correlated with a reduction in Bacteroides and a loss of reportedly beneficial microbes in NORA subjects. The inflamed joints and systemic inflammation characteristic of early rheumatoid arthritis (RA) have been linked with an altered pattern of gut microbial colonization, suggesting a new explanation for autoimmunity and having potential implications for treatment, researchers reported. Using shotgun gene sequencing, a group of researchers led by Dan L. Littman, MD, PhD, of New York University found that 75% of patients with new-onset, untreated RA had a distinct predominance of intestinal microbiota, with an expansion of pro-inflammatory Prevotella copri. In contrast, that pattern was only seen in 11.5% of patients with longstanding RA (P
Posted on: Sat, 09 Nov 2013 16:40:18 +0000
Trending Topics
Recently Viewed Topics
© 2015