Non-Invasive Technique Controls Size of Molecules Penetrating the Blood-Brain Barrier Innovative ultrasound approach uses acoustic pressure to let molecules through—may help treatment for central nervous system diseases like Parkinson’s and Alzheimer’s. The research is in Journal of Cerebral Blood Flow & Metabolism. (full access paywall) Research: “The size of blood–brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure” by Hong Chen and Elisa E Konofagou in Journal of Cerebral Blood Flow & Metabolism. doi:10.1038/jcbfm.2014.71 Image: Damage analysis of BBB-opened brain regions: Histological examination of (A, C) left (BBB-opened) and (B, D) corresponding right (no ultrasound) hippocampi. No microscopic tissue damage was observed in the BBB-opened hippocampus at 0.51 MPa (A), same as in the intact right hippocampus on the same section (B). Minor microhemorrhage is noticeable in one location (box) in the hippocampus sonicated at 0.84 MPa (C), compared to no damage in nonsonicated hippocampus (D). The insert shows magnified image of the region in the box. Scale bar represents 1 mm. Credit Elisa Konofagou/Columbia Engineering. #parkinsons #neurology
Posted on: Thu, 14 Aug 2014 22:12:16 +0000
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