Optimal management of hypothyroidism, hypothyroxinaemia and - TopicsExpress

Optimal management of hypothyroidism, hypothyroxinaemia and euthyroid TPO antibody positivity pre-conception and in pregnancy Clinical Endocrinology, 12/09/2014 Chan S, et al. – The prevention of significant adverse obstetric and neurodevelopmental outcomes from hypothyroidism requires a strategy of empirical levothyroxine dose increases and predictive dose adjustments in pregnancy combined with regular thyroid function testing, starting before pregnancy and until the postpartum period. Treatment of this condition in pregnancy may be considered in those with underlying thyroid autoimmunity. Whilst the evidence for a link between the presence of anti–TPO antibodies and increased risks of pregnancy loss and infertility is compelling, the results of ongoing randomised trials of levothyroxine in euthyroid women with underlying autoimmunity are currently awaited.

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