Question of the Day !!! Compare the metabolism of orally consumed marijuana to that of inhaled marijuana!!! Consuming moderate to high quantities of marijuana orally, such as in food or in a tincture (a liquid-based solution), will yield a different and sometimes more intense outcome as compared to the outcome after inhaling marijuana. Individuals who ingest marijuana will typically not begin to feel any psychoactive or physiological effects of the plant for at least 45 minutes to 90 minutes after ingestion. This delayed onset makes it more difficult for subjects to regulate their dosage. Also, the psychoactive and physiological effects of marijuana tend to last significantly longer after oral consumption of cannabis as compared to after inhaled cannabis. (After oral consumption, the psychoactive and physiological effects of marijuana tend to last four to six hours.) When cannabis is inhaled, THC passes rapidly from the lungs to the bloodstream and to the brain. By contrast, when cannabis is consumed orally, a significant portion of THC is converted into the metabolite 11-hydroxy-THC before reaching the brain. (Inhaling cannabis produces only trace levels of this chemical.) Since 11-hydroxy-THC is believed to be slightly more potent than THC and possesses greater blood-brain-barrier penetrability, the physical and psychoactive effects may be magnified in some consumers. Some users prefer these longer-lasting effects, particularly those seeking to treat chronic conditions. Other consumers, such as those seeking occasional symptomatic relief prefer the milder, shorter-lived effects associated with inhalation...
Posted on: Sun, 26 Jan 2014 14:25:07 +0000
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