Researchers have provided evidence that blocking a signaling pathway involving proteins known as JAKs (Janus kinases) can inhibit tumour growth in preclinical models of bowel cancer and human bowel cancer cells that have high levels of Wnt signaling – and since more than 80% of bowel cancers are driven by a defect in the Wnt signaling pathway, this discovery could have a lot of potential! Read more: bit.ly/1xGbVFs The potential of JAK inhibitors for treating bowel cancer Publication: “Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration.” Science Signaling vol. 7, issue 345. DOI: 10.1126/scisignal.2005411 Image: zoe J/Flickr
Posted on: Thu, 02 Oct 2014 15:48:22 +0000
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