Sarin is an organophosphate nerve agent and is one of the most - TopicsExpress

Sarin is an organophosphate nerve agent and is one of the most toxic chemical warfare agents known. Sarin is absorbed rapidly through the eyes, respiratory tract and skin. Nerve agents irreversibly inactivate acetylcholinesterase, producing an accumulation of acetylcholine at cholinergic receptors. This may then lead to: Muscarinic receptors: miosis, increased salivary, bronchial and tear secretion, bronchoconstriction, vomiting, diarrhoea, urinary and faecal incontinence, bradycardia Nicotinic receptors: sweating, muscle weakness and flaccid paralysis Central nervous system: irritability, giddiness, fatigue, lethargy, amnesia, ataxia, seizures and respiratory depression Stimulation of the adrenal medulla causes tachycardia and hypertension

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