Scopolamine (USAN), hyoscine (BAN) also known as levo-duboisine or burundanga,[4] sold as Scopoderm, is a tropane alkaloid drug with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane, jimson weed (Datura), angels trumpets (Brugmansia), and corkwood (Duboisia).[5][6] Scopolamine exerts its effects by acting as a competitive antagonist at muscarinic acetylcholine receptors, specifically M1 receptors[citation needed]; it is thus classified as an anticholinergic, antimuscarinic drug. (See the article on the parasympathetic nervous system for details of this physiology.) Its use in medicine is relatively limited, with its chief uses being in the treatment of motion sickness and postoperative nausea and vomiting.[2][7][8] Scopolamine is named after the plant genus Scopolia.[6] The name hyoscine is from the scientific name for henbane, Hyoscyamus niger.[9] It is on the World Health Organizations List of Essential Medicines, a list of the most important medication needed in a basic health system.
Posted on: Wed, 19 Nov 2014 17:15:11 +0000
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