Sean D. McAllister, PhD cpmc.org/professionals/research/programs/science/sean.html Pierre Desprez, PhD cpmc.org/professionals/research/programs/science/desprez.html ...our studies have identified Id-1 as a critical regulator of breast cancer progression and suggest the feasibility of developing novel therapeutic approaches to target Id-1 expression to reduce breast cancer metastasis in humans. pnas.org/content/100/23/13543 Recent Research on Cannabinoids. We targeted breast cancer cells that expressed high amounts of the protein Id-1. CBD is highly effective at turning off this specific gene that controls breast cancer metastasis. cpmc.org/professionals/research/programs/science/cannabidiolarticles.html Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Our data demonstrate the efficacy of CBD in pre-clinical models of breast cancer. CBD inhibits human breast cancer cell proliferation and invasion. The results have the potential to lead to the development of novel non-toxic compounds for the treatment of breast cancer... ncbi.nlm.nih.gov/pmc/articles/PMC3410650/ Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells...CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness...reducing Id-1 expression with cannabinoids could also provide a therapeutic strategy for the treatment of additional aggressive cancers because Id-1 expression was found to be up-regulated during the progression of almost all types... mct.aacrjournals.org/content/6/11/2921.long Id-1 is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target...our results establish Id-1 as a key regulator of both invasion and stemness in GBM cells and demonstrate that the non-toxic cannabinoid compound CBD down-regulates Id-1 expression and tumor aggressiveness in culture and in vivo. ncbi.nlm.nih.gov/pmc/articles/PMC3594064/
Posted on: Fri, 08 Aug 2014 03:44:02 +0000
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