Serum 25-Hydroxyvitamin D Levels and Testosterone Deficiency Previous studies have demonstrated that male hypogonadism is associated with a low level of vitamin D. However, no reports have investigated the effects of vitamin D on testosterone levels in Korean men. Our aim was to investigate whether testosterone levels are associated with serum vitamin D levels and whether seasonal variation exists. This cross-sectional study analyzed serum 25-hydroxyvitamin D [25(OH)D], total testosterone (TT), and free testosterone (FT) in 652 Korean men over 40 years of age who had undergone a comprehensive medical examination. The average age of the subjects was 56.7 +/- 7.9 years, and the mean serum 25(OH)D, TT and FT levels were 21.23 +/- 7.9 ng ml-1 , 4.70 +/- 1.6 ng ml-1 , and 8.12 +/- 3.3 pg ml-1 , respectively. In the multiple linear regression model, 25(OH)D showed positive association with TT (beta =0.137, P< 0.001) and FT (beta =0.103, P= 0.008). 25(OH)D and FT showed similar seasonal or monthly variation after adjustment for age. A vitamin D deficiency [25(OH)D < 20 ng ml-1 ] was associated with an increased risk of deficiencies of TT (
Posted on: Wed, 24 Dec 2014 11:39:59 +0000
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