T cell development can be divided into three major regulatory - TopicsExpress

T cell development can be divided into three major regulatory phases by the checkpoints that occur at commitment to the T cell lineage and at β-selection. The three phases are each governed by different gene networks that confer distinct cellular characteristics. The correct developmental programme depends on the sequential operation of these gene networks, and cells that fail to enforce the boundaries between phases may be predisposed to leukaemic transformation

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