The AACT toxicology question of the day for today: What is Samter’s triad? Scroll down for the answer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Samter’s triad is a clinical syndrome characterized by aspirin sensitivity, nasal polyps, and bronchial asthma. The cited reference points out that this is also known as “aspirin exacerbated respiratory disease” or “aspirin sensitive asthma”. The authors note that in this syndrome exposure to aspirin or other cyclooxygenase-I inhibitors results in a spectrum of bronchospasm, laryngospasm, rhinitis, and conjunctivitis. The mechanism for this aspirin intolerance has not been fully elucidated but likely relates to accumulation of leukotrienes and other inflammatory products resulting from dysfunction of the arachidonic acid metabolism pathway. (Shen J et al. Aural polyps in Samter’s triad: Case report and literature review. 2012 Otology and Neurotology 33:774-778)
Posted on: Mon, 17 Mar 2014 13:05:37 +0000
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