The most frequent acid base disturbance (with TCA) is acidosis. - TopicsExpress

The most frequent acid base disturbance (with TCA) is acidosis. This is often a mixed acidosis with both respiratory depression and myocardial impairment/hypotension resulting in reduced tissue perfusion and the production of lactate. Mechanism of ALKALINISATION: This reduction in the pharmacologically active unbound fraction and a direct effect on myocardial contractility by correcting the metabolic acidosis present, were thought to be the causes.

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