The ultimate clinical status and recovery with brain injuries depend upon: ________________________________________ 1. The size and location of the epicenter or core of destruction 2. The surrounding zone of dormant but recoverable neurons fanning out in varying rings from the center core 3. The asymmetry involved 4. The organization and reorganization with plasticity of altered and non- impaired sensory and motor brain functions 5. Meshing of sensory and motor fibers at the brain stem cord junction. In severe neurological conditions, where there is no matrix, pressurized oxygen has beneficial effects in that it: 1. Restores the integrity of the blood-brain barrier and cell membranes, 2. Reduces cerebral edema, 3. Reduces intracranial pressure, 4. Neutralizes toxic amines, 5. Increases neovascularization, 6. Acts as a scavenger of free radicals, 7. Efficiently elevates diffusional driving force for oxygen thereby increasing tissue oxygen availability, 8. Promotes phagocytosis, (thereby internal debridement), 9. Stimulates angiogenesis and reactivates idling neurons. More work in this area is encouraged . . . Philip James MD Reference: Gottlieb SF, Koehler GJ, Rhodes LVG. An oxygen- and pressure-sensitive enzyme: NaK adenosinetriphosphatase. In: CJ Lambertson (ed), Underwater Physiology V, Proceedings of the Vth Symposium on Underwater Physiology, FASEB, Bethesda, 1976, pp:431-442. Gottlieb SF, Schmitt PL.: Effects of increased pO2 on activity of Na-K-ATPase during purification from beef brain cortex: existence of new controlling mechanism? Undersea Biomed Res 8:28-29, 1981. Schmitt PL, Gottlieb SF.: Enhancement of cortical Na*, K*. - ATPase by increased oxygen tensions: evidence of a new controlling mechanism. Brain Res 242: 271-278., 1982. Van Meter K, Lasater S. hbot4u 909.477.4545
Posted on: Sun, 28 Sep 2014 16:46:47 +0000
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