Varenicline tartrate is a partial nicotinic agonist that acts on - TopicsExpress

Varenicline tartrate is a partial nicotinic agonist that acts on α4β2 nicotinic receptors. It alleviates withdrawal discomfort but also diminishes rewarding effects of cigarettes smoked if patients lapse when using the drug.Standard varenicline tartrate dosing (a gradual increase to 2 mg/d) was formulated to avoid adverse effects (primarily nausea) in sensitive patients. The latest findings suggest that the limits to treatment response to varenicline may be due to factors other than insufficient dosage. Above the standard dosage, there may be no further relevant effects on the target nicotinic receptors.Increasing the medication dose suggests that this approach may not work with varenicline. original article: adf.ly/vlsJd archinte.jamanetwork/article.aspx?articleid=2038988

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