ptic Ulcer *Drug Therapy: 1- مضادات الحموضة **************** I- Chemical antacids ************************** 2- Calcium Carbonate Advantage* 1- Quick onset. 2- Long duration. Disavantages* 1- Carbon Dioxide release causing distintion, discomfort ,& rebound Hyperacidity 3- Constipation 4- Hypecalcemia & Hypercalcuria 5- Incraese Gastrin secration causing rebound hyperacidity 6- Milk- Alkali syndrome ********************************* 3- Magnesium Oxide & Hydroxide (Milk Magnesia) Advantages* 1- No carbon Dioxide release 2- No systimic alkalosis or alkaline urine 3- Long duration Disadvantages* 1- Delayed onset 2- laxative effect *********************** 4- Magnesium Trisilicate Mg Trisilicate + HCl -------------> MgCl2 + H2O + Silicon Sioxide gel Advantages* 1- Very effective antcide acts Chemically & physically Chemically by neutralizing HCl Physically by Formation of silicon dioxide gel: - Adsorb HCl & pepsin - Demulcent effect on ulcer floor 2- No carbon dioxide release 3- No systimic alkalosis 4- long duration 5- Useful in patient with constipation Disadvantages* 1-Delayed action 2- Laxative Effect Dose: 1g ***************************** 5- Aluminum Hydroxide Gel Advantages* 1- Very effective antcide acts Chemically & physically 2- No carbon dioxide release 3- No systimic alkalosis 4- long duration 5- Useful in Patient with diarrhea Dose: 8 ml Disadvantages* 1- Astringent --------> treated by adding Mg Trisilicate and used as combination 2- Decrease absorption of phosphate -------> hypophospatemia 3- Cause toxicity if used in case of renal impairment ************************ 6- Magaldrate * Magnesium Hydroxide + Aluminum Hydroxide
Posted on: Sat, 01 Feb 2014 08:27:08 +0000
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