Answer to yesterday’s quiz: Which one of the following statements about clomiphene citrate is true? A. It is an aromatase inhibitor. B. It has a high efficacy rate among women with infertility. C. It is associated with a relatively high multiple pregnancy rate as compared with the rate associated with unassisted conception. D. It typically has minimal side effects. The answer is C. Clomiphene citrate is a selective estrogenreceptor modulator that antagonizes the negative feedback of estrogen at the hypothalamus with a consequent increase in ovarian stimulation by endogenous gonadotropin. Clomiphene has drawbacks, including its overall poor efficacy (only a 22% rate of live birth with up to six cycles of clomiphene in one study), a relatively high multiple-pregnancy rate (3 to 8%) as compared with the rate associated with unassisted conception (
Posted on: Sun, 13 Jul 2014 15:00:01 +0000
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