I have some major news for migraineurs out there!! An article was written by a couple of scientists and a doctor-researcher from Mayo Clinic on migraines and how they now can visualize what they call (and you will be able to read on Monday at HormonesMatter) Spreading Cortical Depression (SCD) and depolarized regions of the brain (what I called the neurons that don;t have enough salt to create electricity. They also write about the migraine sufferers being the sensitives as I did in my book. So I wrote to him an email telling him how exciting it is that they have found exactly the same thing I have written about in my book Fighting the Migraine Epidemic ( bookstore.authorhouse/Products/Default.aspx?bookId=SKU-000722338 ) and how amazing to actually see the depolarized region and the following electrical challenge by neighboring neurons to wake the ones not working up using SCD. I asked if we could work together since I also have the suspicion that Fibromyalgia (FM) has the same basic foundation. I did not expect a response!!! Here is what I got today: Dr. Stanton, Thank you for your e-mail and sorry about the delay in responding. Like you, I certainly believe that the person with migraine (and likely people with other disorders of central sensitivity – e.g. Fibromyalgia) is hypersensitive to sensory stimuli of many different modalities. Evidence for this comes from patient report of symptoms, from physiologic tests that show people with migraine to have lower sensory discomfort thresholds (e.g. Thresholds for discomfort from light, sound, painful stimulation of the skin) and functional imaging studies showing that the migraine brain responds more exuberantly than the brain of someone without migraine when exposed to sensory stimuli. Another important aspect when considering these hypersensitivities is the lack of habituation to repetitive stimuli that is present in migraine patients between migraine attacks. Whereas a healthy person will respond progressively less to repetitive stimuli (I.e. They adapt to the repetitive stimuli), the person with migraine does not habituate (I.e. They do not adapt the repetitive stimuli, but keep responding to it like it is a novel stimulus). Although I am not certain about the timing of onset for these sensory hypersensitivities, I am suspicious that they might be present from birth. It has recently been shown that infantile colic is more common in people who go on to develop migraine and motion sickness during childhood is also associated with development of migraine. It is likely that infantile colic and motion sickness are both at least partially attributable to sensory hypersensitivity. I am interested in your comments about using salt, water, and electrolytes for migraine treatment. Although I dont yet have a well-formulated opinion on this, I can say that administration of IV fluids (normal saline) is part of the standard-of-care for treating migraine in the Emergency Department and the fluids do seem to help (although they are really never administered alone without medication). I look forward to reading your book. Sincerely, Todd Todd J. Schwedt, MD MSCI Associate Professor of Neurology Mayo Clinic So I sent my book to him today and it seems he is in full support and is (it appears) open to further work on the matter. I think that it will be easy to convince him (I have yet to write a response) to check giving IV only and wait.... I think the chance is here for me now to break into the medical system with my book and change how migraine is treated! It would be so exciting to wipe migraine off the planet!! Hugs to you all! What a way to start the weekend!
Posted on: Fri, 14 Nov 2014 20:19:15 +0000
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