Lung Cancer Genetics The gene known to be mutated most frequently - TopicsExpress

Lung Cancer Genetics The gene known to be mutated most frequently in lung cancers is P53. P53 mutations are found in about 50% of NSCLC and in over 90% of SCLC. Many smoking-associated mutations are G→T transversions that occur in known hotspots of the P53 open reading frame. These characteristic mutations can be directly attributed to bulky adducts caused by exposure to BPDE, a carcinogen in cigarette smoke.

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