([1]. Studies demonstrating the presence of inflammatory cells and their products in the brain lesions of MS patients, in addition to reports from animal models, has led to the generally accepted hypothesis that disease is mediated by pathogenic T cell responses against myelin antigens, followed by a broader neurodegenerative process [2]. The autoreactive T cells migrate across the blood–brain barrier (BBB) and mediate damage against the central neurones and their myelin sheaths, in particular, but also their axons.)so that means T cells are the main triggers of MS 2nd In the case of S. pyogenes, the bacteria produces a toxin known as a superantigen, which activates white blood cells called T-cells, causing an overproduction of proteins called cytokines. These wreck havoc on cells.)((KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis)STAPHYLOCOCCUS PYOGENES is a causing agent of the flesh eating bacteria,as i read more there seem to be a possible link between the disease and HLA B27 2nd The patients with bacterial arthritis present with fever in 60 to 80% of cases. While most patients have mild fever, a third have temperature exceeding 39oC. Due to differences in clinical features and aetiologic agent, the two forms of septic arthritis, i.e., gonococcal arthritis and nongonococcal arthritis, are usually considered as entities of their own. Table 1. Bacteria Which Are Most Commonly Isolated from Synovial Fluid of Patients with Bacterial Arthritis* Gram-positive strains Staphylococcus aureus Staphylococcus epidermidis, and other coagulase negative staphylococci Streptococci Streptococcus pyogenes
Posted on: Sat, 15 Nov 2014 19:41:22 +0000
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