Hematopoietic Stem Cells (HSC)s Gene therapy to achieve long term HIV resistance. Substantial progress has been made in developing a new therapeutic approach using gene therapy through HSCs to attempt to confer long-term resistance against HIV. HSCs are capable of self-renewal and differentiation into all hematopoietic lineages. In theory, gene therapy approaches that introduce protective genes against HIV via HSCs can continuously produce their anti-HIV genes in all differentiated cells, including HIV target cells such as CD4+ T lymphocytes and macrophages. Successful replacement of a patient’s immune system by gene modified HIV protected cells may have the potential to minimize viral loads as well as reduce reservoirs of infected and latently infected cells. Newly differentiated protected cells may prevent viral production and spread from persistently infected cells and may allow the functional restoration of the damaged immune system. Currently, a significant clinical benefit by HSC-based gene therapy approaches for HIV diseases has not been achieved; however, this approach has the potential to provide long-term control of HIV through a single treatment. If successful, gene therapy through stem cells could free patients from lifelong daily medications and significantly impact their quality of life and relieve many people from the fear of this deadly disease. So Its up to us to further take this promising mechanism down cutting edge researches in an attempt to combat HIV and probably cure!...
Posted on: Tue, 01 Oct 2013 18:31:05 +0000
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