Modern Pathology 26, 967-974 (July 2013) | doi:10.1038/modpathol.2012.233 HPV L1 DETECTION DISCRIMINATES CERVICAL PRECANCER FROM TRANSIENT HPV INFECTION: A PROSPECTIVE INTERNATIONAL MULTICENTER STUDY Grit Mehlhorn, Ellen Obermann, Giovanni Negri, Lukas Bubendorf, Christine Mian, Martin Koch, Heinz Sander, Birgit Simm, Markus Lütge, Zsuzsanna Bánrévi, Anke Weiss, Gieri Cathomas, Ralf Hilfrich, Matthias Wilhelm Beckmann and Henrik Griesser Abstract The benefits of cytology-based cervical cancer screening programs in reducing morbidity and mortality are well recognized. Especially, overtreatment of human papillomavirus (HPV) high-risk positive early dysplastic lesions may have a negative impact on reproductive outcomes for fertile women. To optimize the clinical management an objective standard is needed to distinguish precancer that requires treatment, from spontaneously resolving HPV infections. In the current study, we examined the prognostic relevance of HPV-L1 capsid protein analysis with Cytoactiv in an international prospective multicenter study including 908 HPV high-risk positive early dysplastic lesions (LSIL/HSIL) during a follow-up period of 54 months. The clinical end points of the study were histologically confirmed CIN3+ as progression, CIN1/2 for stable disease and repeated negative Pap smears as spontaneous clinical remission. The difference of the clinical outcome of HPV-L1-negative and HPV-L1-positive cases was statistically highly significant (P-value
Posted on: Tue, 02 Jul 2013 00:05:26 +0000
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