Talk: Left-Right asymmetry: Lessons from Drosophila Speaker: Prof. Stéphane Noselli, Director, Institute of Biology, CNRS, Nice, France. Date: 25th November 2014, Tuesday Time: 5:00 pm Venue: Seminar Room 34, 2nd Floor, Main Building Abstract: Breaking Left-Right (LR) symmetry in Bilateria is a major event in body plan organization. LR asymmetry is essential for positioning visceral organs, but is also essential for asymmetric morphogenesis and function of the heart and brain. Work using vertebrate models has revealed a number of original mechanisms underlying LR development, including the ‘nodal flow’, ‘ion flows’ and ‘cellular flow’. Although Drosophila represents a major model to study body patterning, LR asymmetry remained uncharacterised in this organism until recently. Here, I present our current knowledge on genes, pathways and mechanisms underlying establishment of LR asymmetry in Drosophila and will discuss how these findings fit and contribute to our general understanding of LR asymmetry across phyla. In particular, I will describe specific organ LR organizers (genitalia, gut) and show how the Hox gene Abd-B and the conserved type ID myosin (MyoID) genes work together to control LR development in Drosophila and during evolution.
Posted on: Fri, 21 Nov 2014 10:05:52 +0000
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