The study adds growing evidence that fish oils, once viewed as a holy grail in cardiovascular medicine, are limited in their clinical utility. Fish oil, composed primarily of n-3 polyunsaturated fatty acids (n-3 PUFAs), is thought to directly prevent inflammation, oxidative stress, and atrial remodeling. But in the Jan. 15 issue of the American Journal of Cardiology, Leon Darghosian, M.D., C. Michael Stein, M.B.Ch.B., and colleagues investigated the effect of high dose n-3 polyunsaturated fatty acids (n-3 PUFAs) – as an adjuvant to a patient’s existing antiarrhythmic regimen – on the recurrence of AF. They also examined the effects of n-3 PUFAs on oxidative and inflammatory markers, including F2IsoP and IL6, respectively. Not only did their results reveal that a high-dose n-3 PUFA regimen failed to reduce the frequency of AF, they discovered that there was no significant reduction in the studied inflammatory and oxidative markers. sciencedirect/science/article/pii/S0002914914020104
Posted on: Thu, 15 Jan 2015 10:47:16 +0000
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