Έρευνες » Αντιβακτηριδιακή δράση της μαστίχας » Journal of Ethnopharmacology, Vol. 15, Issue 13, March 1986, Pages 271- Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity Mansoor S. Al-Said, A. M. Ageel, N. S. Parmarand* M. Tariq Departments of Pharmacology & Pharmacognosy and the Research Centre, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia Abstract The effect of mastic, a concrete resinous exudate obtained from the stem of the tree Pistacia lentiscus, has been studied on experimentallyinduced gastric and duodenal ulcers in rats. Mastic at an oral dose of 500 mg/kg produced a significant reduction in the intensity of gastric mucosal damage induced by pyloric ligation, aspirin, phenylbutazone, reserpine and restraint + cold stress. It produced a significant decrease of free acidity in 6-h pylorus-ligated rats and a marked cytoprotective effect against 50% ethanol in rats, which could be reversed by prior treatment with indomethacin. The protective effect was not seen when it was given intraperitoneally in phenylbutazone and restraint + cold stress models. The reduction in the intensity of ulceration in cysteamine-induced duodenal ulcers was not found to be statistically significant in mastic-pretreated rats. The results suggest that mild antisecretory and a localized adaptive cytoprotectant action may be responsible for its anti-ulcer activity. These observations support the results of an earlier study on the clinical effectiveness of mastic in the therapy of duodenal ulcer.
Posted on: Wed, 04 Sep 2013 12:44:57 +0000
Trending Topics
Recently Viewed Topics
© 2015