...Glycine... does not have a side chain and, as mentioned earlier in the discussion of the basics principles of protein structure, it allows high flexibility in the polypeptide chain, as well as torsion angles, which are normally not allowed for other amino acids residues. That is why glycine is often found in loop regions, where the polypeptide chain makes a sharp turn. This is also the reason for the high conservation of glycine residues in protein families, since the presence of turns at certain positions is a characteristic of a particular fold of a protein structure. Reference: proteinstructures/Structure/Structure/Ramachandran-plot.html
Posted on: Wed, 21 Jan 2015 06:44:37 +0000
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